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198 Several pathways have been implicated in micropinocytosis events, such as the ERK/MAPK pathway activated by oncogenic RAS, and PI3K/mTOR signalling pathways

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Because the triple-receptor design distinguishes it from earlier single- and dual-agonist peptides, the published literature has grown along an unusually legible arc: a founding discovery paper, a structural-biology study resolving how one peptide can occupy three distinct receptor complexes, and a sequence of clinical trials that broadened from glycemic endpoints into obesity and liver-fat endpoints